Summary

Proline is a nonessential amino acid that occurs in high amounts in collagen tissue and also promotes the formation of bone, skin, and cartilage. It is extremely important for the proper functioning of joints and tendons. However, it can be synthesized from either ornithine or glutamic acid in the body. So as long as we consume sufficient protein, we should get enough proline.

Other names for Proline

PRO, amino acid P

Where to find Proline

Proline is one of the main components of collagen, which is found in the tendons, ligaments, and connective tissue in the body. It is also found in dairy products, eggs, and meat.

Popup: Foods highest in Proline

Why athletes use Proline

Proline may prove to be useful for athletes in terms of ensuring proper function of joints and tendons. It is also thought to play a role in tissue repair and wound recovery. However, it's not necessary to consume it as a single nutrient. As long as you consume enough protein, your needs should be covered.

Ways that Proline can enhance Muscle Gain & Recovery:

• Important for the functioning and repair of joints and tendons

Ways that Proline can enhance Longevity:

• Help maintain and strengthen the heart muscle

Signs of Proline deficiency

No deficiency conditions are known to exist.

Potential uses for Proline

Research indicates that Proline may be useful in the treatment of:

• Acidemia
• May aid in reduction of atherosclerotic plaque deposits

More about Proline

Proline is a nonessential amino acid that occurs in high amounts in collagen tissue and also promotes the formation of bone, skin, and cartilage. It's extremely important for the proper functioning of joints and tendons. However, it can also be synthesized from either ornithine or glutamic acid in the body.

Although proline plays an integral role in collagen (collagen fibers are found in the tendons, ligaments, and connective tissues of the body), it is not something we are typically deficient in. As long as we consume enough protein from foods and/or supplements, we should get a sufficient supply of proline to reap the benefits of this amino acid.

Amount

It is very rare for proline to be taken as a single nutrient. It's typically found as part of the total protein count in foods and protein supplements.

Timing

There is no specific best timing for consumption of proline.

Synergists of Proline

Vitamin C helps in the cross-linking between proline and lysine in connective-tissue formation.

Toxicity of Proline

No known toxicity.

Bans and restrictions

None reported.

• Adam, M., et al., "Contribution to the Mode of Action of Glycosaminoglycan-Polysulphate (GAGPS) upon Human Osteoarthrotic Cartilage. Biochemical Study of the Collagen and Proteoglycan Turnover," Arzneimittelforschung 30.10 (1980) : 1730-2.
  
• "Alleviating Arthritis. Can Gelatin Promote Joint Health?" Johns Hopkins Med Let Health After 50. 10.6 (1998) : 8.